Nanoparticles help to break up the blood clots that cause strokes

Standard of care in the setting of an acute stroke is to treat patients with tPA, tissue plasminogen activator, also known as “the clot buster”, which breaks apart blood clots upon contact. However, the procedure can be dangerous in patients prone to bleeding because tPA sometimes can affect other parts of the vessel and even cause hemorrhage in other parts of the body. Paolo Decuzzi at the Houston Methodist Research Institute has engineered tPA-coated nanoparticles that become trapped in the clot and cannot affect other tissues.

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