Can we start using menopausal estrogen replacement again safely?

The swinging pendulum is observed in every aspect of medicine, including the use of menopausal estrogen replacement therapy. Estrogen is the wonder drug for women undergoing menopause and experiencing many menopausal symptoms including hot flashes,  sexual dysfunction, and mood changes. The Women’s Health Initiative study (WHI) has published results in 1991, 2002, 2010, and 2017 that caused the pendulum to swing back and forth regarding the safety of estrogen replacement therapy. The latest extension from WHI seems to favor the use of estrogen.

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