3-D human ‘mini-brains’ shed new light on genetic underpinnings of major mental illness

Researchers at Brigham and Women’s are using new technology to research genetic determinants of mental health in which stem cells are used to grow a replica of a human brain.  Using this, they were able to find the specific molecular and structural  effects a the mutation in the gene DISC1. Specifically, they found that the mutation leads to structural changes in the brain that are directly linked to increased WNT signaling and that those changes are reversed when the pathway is inhibited. Will these have therapeutic significance in the near future?

full article; https://www.sciencedaily.com/releases/2018/04/180419141530.htm

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